The Compendium · Volume I

Twelve compounds. Read like a library.

A monograph of the molecules we formulate with — their classification, their mechanism, the evidence base, and the dosage your protocol is built upon. No proprietary blends. No hidden math. Only the literature, made legible.

Compounds in the formulary

Cognitive blends, indexed

36+

Peer-reviewed citations

§ 01 The Index

The full formulary, at a glance.

RR Energy

Rhodiola RoseaRoseroot · Arctic root

CE Energy

Coenzyme Q10Ubiquinone · Ubiquinol

AG Energy

Asian GinsengPanax · True ginseng

LT Energy

L-TyrosineAmino acid · Catecholamine precursor

ASH Sleep

AshwagandhaWithania somnifera · Indian ginseng

LTH Sleep

L-TheanineTheanine · Amino acid

A Sleep

ApigeninChamomile flavone

CA Anxiety

Centella AsiaticaGotu Kola · Brahma-Buti

LB Anxiety

Lemon BalmMelissa officinalis · Bee Balm

BM Focus

Bacopa MonnieriBrahmi · Water hyssop

AGPC Focus

Alpha-GPCCholine alphoscerate

MT Focus

Magnesium ThreonateMagtein · L-Threonate

§ 02 Energy

№ 01 RR

Rhodiola Rosea

Rhodiola rosea L.

Dose250mg

Adaptogen Cognitive Mental Resilience

Overview

An adaptogenic herb native to the arctic regions of Europe, Asia, and the Americas. Its root extract has a long traditional use as an anti-fatigue agent, with pharmacological evidence supporting effects on mood and cognitive function.

Mechanism & Evidence

Rhodiola has been studied for its capacity to enhance mental performance and reduce both physical and mental fatigue, particularly under stressful conditions. Clinical research also points to a positive effect on athletic performance — reducing pain and muscle damage following exercise — and on subjective measures of stress resilience.

Classification

Adaptogen — a class of compounds that modulate the body's stress response without acting as stimulants.

Also known as: Roseroot · Golden root · Arctic root

3peer-reviewed citations Dailystandard regimen

№ 02 CE

Coenzyme Q10

Ubiquinone · Ubiquinol

Dose100mg

Antioxidant Mitochondrial Fatigue

Overview

A molecule produced endogenously by the body. CoQ10 supports mitochondrial energy production and forms part of the body's antioxidant defence system, protecting cells from oxidative stress. It is also obtained dietarily from sources such as meat and fish.

Mechanism & Evidence

In the literature, CoQ10 has been shown to be a safe and effective supplement for reducing the symptoms of fatigue and lowering markers of oxidative stress. Its role in the electron transport chain is foundational — making it a candidate for any protocol concerned with cellular energetics and metabolic resilience.

Classification

Endogenous antioxidant and mitochondrial cofactor. Two principal forms — ubiquinone and ubiquinol — are interconverted in the body.

Also known as: CoQ10 · Ubiquinone · Ubiquinol

3peer-reviewed citations Dailystandard regimen

№ 03 AG

Asian Ginseng

Panax ginseng C. A. Mey.

Dose500mg

Adaptogen Memory Vitality

Overview

A plant native to Eastern Russia, north-eastern China, and the Korean peninsula. Considered an adaptogen and used in traditional Chinese medicine across a wide range of contexts — both alone and in formal compound formulations.

Mechanism & Evidence

Several studies suggest Asian Ginseng is a promising agent for treating fatigue and supporting energy levels. Other research points to benefits for memory and overall cognition. Its bioactive ginsenosides act on multiple pathways — neuroprotective, immunomodulatory, and metabolic — making it a versatile, well-studied entry in any energy-oriented stack.

Classification

Adaptogen. Distinct from American ginseng (P. quinquefolius) and Siberian ginseng (Eleutherococcus) in both phytochemistry and effect.

Also known as: Ginseng · Korean ginseng · Panax ginseng · True ginseng

3peer-reviewed citations Dailystandard regimen

№ 04 LT

L-Tyrosine

Amino acid · Catecholamine precursor

Dose1000mg

Neurotransmitter Dopamine Norepinephrine

Overview

An amino acid found in high concentrations in animal protein, dairy, and whole grains. Tyrosine is an essential precursor in the production of two of the brain's most consequential neurotransmitters: dopamine and norepinephrine.

Mechanism & Evidence

Tyrosine has been shown to enhance cognitive performance under stressful and cognitively demanding conditions — precisely the contexts in which dopamine and norepinephrine become depleted. By replenishing the substrate for these neurotransmitters, tyrosine supports memory and mood under load. This makes it particularly relevant for protocols designed to absorb high-pressure, high-output days.

Classification

Conditionally essential amino acid; non-essential under typical conditions but rate-limiting during acute stress.

3peer-reviewed citations As-neededload-day regimen

Every dose in our formulary is matched to the concentration studied in peer-reviewed neuroscience — not engineered for cost.

— The Cognitive Care Standard

§ 03 Sleep

№ 05 ASH

Ashwagandha

Withania somnifera (L.) Dunal

Dose400mg

Adaptogen Stress Sleep Quality

Overview

A shrub native to parts of Africa and Asia, Ashwagandha occupies a central place in Ayurveda — India's traditional medical system. It is classified as an adaptogen and is used to reduce stress, attenuate anxiety, and improve sleep quality.

Mechanism & Evidence

Ashwagandha modulates the body's response to stress, which in turn reduces anxiety. A growing body of clinical evidence supports its use for improving overall sleep quality — both in individuals with insomnia and in those with no diagnosed sleep disorder. The withanolides, its principal active class, appear to influence cortisol regulation and GABAergic signalling.

Classification

Adaptogen with anxiolytic and sleep-promoting properties. The species name, somnifera, means "sleep-inducing" in Latin.

Also known as: Withania somnifera · Indian ginseng · Smell of Horse · Winter Cherry

3peer-reviewed citations Eveningregimen

№ 06 LTH

L-Theanine

Theanine · γ-Glutamylethylamide

Dose200mg

Cognitive Anxiety Neuroprotective

Overview

Theanine is a naturally occurring amino acid found in tea and certain mushroom species. The L-theanine isomer is the most common form — and the form taken for centuries to soften the jitters that accompany caffeinated tea.

Mechanism & Evidence

Current evidence shows L-Theanine helps to reduce stress and anxiety in individuals experiencing acutely stressful situations. It enhances sleep quality by promoting a more relaxed state in the brain, with measurable shifts in alpha-wave activity. Unlike sedatives, it does not impair daytime alertness — making it a quiet, reliable component of an evening protocol.

Classification

Non-protein amino acid; structural analogue of glutamate. Crosses the blood-brain barrier.

Also known as: Theanine

3peer-reviewed citations Eveningregimen

№ 07 A

Apigenin

Chamomile flavone

Dose50mg

Flavone Mood Sleep Quality

Overview

A flavonoid found in several plants and present at notable concentration in chamomile tea — a preparation with a long history of use for anxiety and stress in traditional medicine.

Mechanism & Evidence

Emerging studies show a positive effect on sleep quality. Apigenin's therapeutic potential is underscored by human clinical work using chamomile extract — in which apigenin is the principal active constituent. Collectively, chamomile extract has been reported to alleviate anxiety, improve mood, and relieve pain.

Classification

Flavone with documented affinity for benzodiazepine receptor sites — the proposed mechanism for its anxiolytic effect.

3peer-reviewed citations Eveningregimen

§ 04 Anxiety

№ 08 CA

Centella Asiatica

Centella asiatica (L.) Urb.

Dose200mg

Antioxidant Cognitive Calm

Overview

A herbaceous plant native to tropical regions across Asia, Africa, and Australia. Long established in traditional Chinese, Indian, and Indonesian medicine, where it is sometimes referred to as the herb of longevity.

Mechanism & Evidence

Centella acts as an antioxidant — reducing the oxidative stress burden on the body — and helps attenuate the effects of anxiety-related disorders. Clinical work suggests it improves measures of calmness and reduces anger, which may in turn enhance cognitive functions including memory and attention. Its triterpenoid profile (asiaticoside, madecassoside) is the most studied class.

Classification

Antioxidant botanical with documented effects on oxidative stress markers and subjective measures of calm.

Also known as: Gotu Kola · Asiatic Pennywort · Brahma-Buti

3peer-reviewed citations Dailystandard regimen

№ 09 LB

Lemon Balm

Melissa officinalis L.

Dose300mg

Calm Sleep Cognitive

Overview

Melissa officinalis is a herb — and a tea — traditionally said to induce calmness and improve cognition. The clinical evidence supports its effectiveness at inducing a calmer state and reducing anxiety.

Mechanism & Evidence

Lemon balm reduces the symptoms of anxiety — including nervousness and excitability — and induces feelings of calm and relaxation in those who take it. It can have a mild sedative effect and is also reported to help with anxiety-related sleep disturbance. Its rosmarinic acid content is the most-studied active constituent, with effects on GABA transamination.

Classification

Mediterranean herb in the mint family (Lamiaceae). Used both as a culinary herb and a medicinal preparation.

Also known as: Melissa Officinalis · Melissengeist · Bee Balm · Garden Balm

3peer-reviewed citations Dailystandard regimen

§ 05 Focus

№ 10 BM

Bacopa Monnieri

Bacopa monnieri (L.) Wettst.

Dose300mg

Nootropic Memory Neuroprotective

Overview

A nootropic herb with a long history of use in traditional medicine — both for longevity and for cognitive enhancement. Bacopa is among the most-studied botanicals in the modern nootropic literature.

Mechanism & Evidence

The active extracts in Bacopa Monnieri play a significant role in neuroprotection and have been shown to enhance cognitive functions including memory and learning. Bacopa typically requires sustained supplementation — its effects build cumulatively over weeks rather than presenting acutely. The bacosides, its principal active class, are believed to influence dendritic branching and synaptic plasticity.

Classification

Nootropic and neuroprotective botanical. Member of the Plantaginaceae family.

Also known as: Brahmi · Indian Pennywort · Water hyssop

3peer-reviewed citations Dailycumulative regimen

№ 11 AGPC

Alpha-GPC

Choline alphoscerate · α-GPC

Dose300mg

Cholinergic Memory Learning

Overview

A compound derived from choline — an essential nutrient that plays a central role in the function of the brain, liver, and skeletal muscle. Choline is found in foods such as beef, eggs, and salmon, and Alpha-GPC is also produced synthetically for supplementation.

Mechanism & Evidence

Alpha-GPC is a highly bioavailable source of choline, which the brain uses to synthesise acetylcholine — a neurotransmitter primarily associated with learning and memory. By increasing the substrate available for acetylcholine production, Alpha-GPC supports the cholinergic system that underwrites attention and recall.

Classification

Cholinergic precursor. Crosses the blood-brain barrier more efficiently than alternative choline forms (choline bitartrate, citicoline).

Also known as: Choline Alphoscerate · Alpha-Glyceryl Phosphoryl Choline

3peer-reviewed citations Dailystandard regimen

№ 12 MT

Magnesium Threonate

Magnesium L-threonate · Magtein

Dose400mg

Mineral Memory Sleep

Overview

A highly absorbable form of magnesium, formed by binding magnesium to threonic acid — a soluble derivative of vitamin C. Of the available magnesium salts, threonate is distinguished by its capacity to elevate magnesium concentrations in the central nervous system.

Mechanism & Evidence

Magnesium is an essential mineral for nerve transmission and neuromuscular conduction, and it plays a regulatory role in preparing the brain and body for sleep — quieting the nervous system. Evidence suggests Magnesium Threonate, in particular, supports improvements in memory and cognition. It crosses the blood-brain barrier in a way that more conventional forms (oxide, citrate) do not.

Classification

Magnesium salt with preferential CNS bioavailability. The threonate moiety facilitates transport across the blood-brain barrier.

3peer-reviewed citations Dailystandard regimen

§ 06 What follows

Knowing the compounds is the first step. Building your protocol is the second.

The literature gives us the molecules. Your evaluation gives us the proportions. The protocol — your protocol — emerges from the intersection of the two, and it is refined as you respond to it.

Take the Evaluation

§ 07 A note on dosing

Dosages listed reflect the full per-serving quantity studied in the literature.

Your prescribed dose may differ. Each protocol is a composition — not a sum — and the proportional weighting of each compound is calibrated to your individual cognitive profile. The numbers on this page are the starting point for the design, not the design itself.

All compounds in the Cognitive Care formulary are sourced from research-grade suppliers and arrive with documentation. Cycling and discontinuation guidance is provided as part of every protocol.